李心慰教授

来源:动物医学学院 发稿时间:2019-06-23 浏览次数:

 

研究生导师基本信息表

姓名:

李心慰

性别:

职称:

教授

硕导/博导:

最高学位:

博士

最高学历:

研究生

邮箱:

lixinwei100@jlu.edu.cn

所在专业:

临床兽医学

所研究方向:

动物营养代谢病

讲授课程:

本科生:兽医临床诊断学,兽医内科学,动物医学各论,动物临床病理学

硕士生:临床兽医学进展

教育经历:

2018/12-2019/12 美国伊利诺伊大学香饼分校,访问学者(青年骨干教师)

2010/09-2013/07  吉林大学,博士

2007/09-2010/07  东北农业大学,硕士

2003/09-2007/07  青岛农业大学,学士

工作经历:

2013.09-2015.09   讲师2015.09-2018.09 副教授2018.10-今        教授(破格)

简介

博士,教授。入选江苏省“双创人才——科技副总类”,入选吉林大学“培英计划“人才,入选吉林大学优秀青年教师培养计划,获得吉林省优秀青年基金,吉林大学优秀青年基金。主要从事奶牛营养代谢病预警、发病机制、诊断新方法及防治新技术研究。近五年申请者主持国家和省部级项目8项,总经费300多万元。国家自然科学基金2项、国家科技部十二五科技支撑计划子课题1项、国家十三五重点研发计划子课题1项、吉林省科技厅项目2项。参加国家863项目、国家973项目和国家自然基金重点项目等项目。目前以第一/通讯作者在Journal of Dairy ScienceAntioxidants Redox Signaling等国际知名期刊发表SCI论文60篇,总影响因子173.9ESI高被引文章5篇,总他引995次,单篇最高他引87次。以主编出版专著两部,副主编出版教材2部。现已授权国家发明专利1项,申报发明专利6项。获得美国乳业协会颁发的最具影响力论文奖、吉林省青年科技奖、获吉林省自然科学学术成果奖二等奖和三等奖各一项。国际学术会议报告5次,并主持分会会议1次。担任本领域顶级期刊Journal of  Dairy Science(国内兽医学唯一入选)、Journal of dairy research(亚洲区唯一代表)、 Universal Journal of Pharmaceutical researchJournal of Veterinary Science and Research学术编委。WOS科学家影响力数据库显示在全球奶牛代谢病研究领域前100名研究者中排名第8位。

在应用研究方面,共研发诊断和防治产品6项,预警系统1套,综合防控技术1套。相关产品和技术现已连续五年在东北三省推广应用14个牧场,惠及3.86万头奶牛,应用47.5万头次。

科研项目:

主持课题如下:

1. 国家自然科学基金面上项目,31772810,线粒体功能紊乱与炎症在奶牛脂肪肝肝脂代谢紊乱中的作用机制,2018/01-2021/1260万,在研,主持

2. 十三五国家重点研发计划,2016YFD0501206,牛羊碳水化合物、蛋白质与能量代谢失衡防控技术研究,2016/07-2020/12100万,在研,主持

3. 十二五国家科技支撑计划,2012BAD12B03-2,围产期奶牛酮病和皱胃变位群体检测体系的建立,2012/12-2016/1260.5万,结题,主持

4. 国家自然科学基金青年基金项目,31402265SREBP-1c/Cidea信号通路在能量负平衡奶牛肝脂沉积中的作用机制,2015/01-2017/1225万,结题,主持

5. 吉林省科技厅自然科学基金面上项目,20170101148JC,高NEFA血症抑制酮病奶牛中性粒细胞胞外诱捕网形成的分子机制,2017.01- 2019.1210万,在研,主持

6. 吉林省科技厅青年科研基金项目,20160520063JH,防治围产期奶牛能量代谢障碍性疾病的新型微生态制剂的研制及效果评价,2016/01- 2018/126万,在研,主持

7. 黑龙江省牛病防制重点实验室开放项目,PCBD201701,线粒体功能紊乱在奶牛酮病肝脂代谢紊乱中的作用机制,2017/09-2019/092万,在研,主持

8. 中央高校基本科研业务费专项资金项目,451160301167,酮病奶牛中性粒细胞免疫功能低下的信号机制,2017.01- 2018.125万,在研,主持

9. 吉林大学交叉学科项目,450060501485,高NEFA和高BHBA血症诱发围产期能量负平衡奶牛胰岛素抵抗的机制,2014/05-2016/055万,结题,主持

10. 吉林大学培英计划,2019.01-2020.0150万,在研,主持

11. 吉林大学优秀青年教师 “重点培养阶段”, 2018.01-2020.12, 20万,在研, 主持

12. 吉林大学优青青年基金,动物营养代谢病,2019.06-2020.0610万,在研, 主持

 

参与课题项目:

1.国家自然基金面上项目,高NEFA和高BHBA血症奶牛血液中性粒细胞免疫机能低下的信号转导机制(31372494), 2014.01-2.17.1288万,在研,参与

2.国家自然基金面上项目,奶牛酮病的氧化应激及其信号转导通路(31172372) 、2011.01-2014.12、  63万,结题,参与

3.国家“863”计划项目子课题,2013AA102806-3、牛羊功能性饲用复合微生物制剂的研制、2013/01-2017/12190万元、在研、参与。

4国家十二五科技支撑项目,奶牛普通病的防治技术(2012BAD12B03-22012.01-2016.12,220万,在研,参与

5、国家重点基础研究发展计划项目(973计划)子课题,2011CB100800、乳脂肪与乳蛋白合成的代谢网络整合与调控、2011/01-2015/1230万元、结题、参与。

学术论文:

[60] Meng Chen, Juan J. Loor, Qian Zhai, Yusheng Liang, Hao Yu, Xiliang Du, Taiyu Shen, Zhiyuan Fang, Zhen Shi, Xinghui Wang, Yiwei Zhu, Yuxiang Song, Guowen Liu, Xiaobing Li, Zhe Wang, Xinwei Li*. Short communication: Enhanced autophagy activity in liver tissue of dairy cows with mild fatty liver. 2020, 103:3628–3635

[59] Li X, Li G, Du X, Sun X, Peng Z, Zhao C, Xu Q, Abdelatty AM, Mohamed FF, Wang Z, Liu G. Increased autophagy mediates the adaptive mechanism of the mammary gland in dairy cows with hyperketonemia. J Dairy Sci. 2020, 103:2545–2555

[58] Xudong Sun, Xiaobing Li, Hongdou Jia, Heyuan Wang, Guanghou Shui, Yonglei Qin, Xin Shu, Yazhe Wang, Jihong Dong, Guowen Liu, and Xinwei Li. Nuclear Factor E2-Related Factor 2 Mediates Oxidative Stress-Induced Lipid Accumulation in Adipocytes by Increasing Adipogenesis and Decreasing Lipolysis. Antioxidants Redox Signaling2020, 32(3):173-192IF5.828

[57] Shen T, Li X, Loor JJ, Zhu Y, Du X, Wang X, Xing D, Shi Z, Fang Z, Li X, Liu G. Hepatic nuclear factor kappa B signaling pathway and NLR family pyrin domain containing 3 inflammasome is over-activated in ketotic dairy cows. J Dairy Sci. 2019, 102(11):10554-10563.IF3.082

[56] Dong J, Loor JJ, Zuo R, Chen X, Liang Y, Wang Y, Shu X, Sun X, Jia H, Liu G, Wang Z, Li X, Li X. Low abundance of mitofusin 2 in dairy cows with moderate fatty liver is associated with alterations in hepatic lipid metabolism. J Dairy Sci. 2019, 102(8):7536-7547

[55] Zhao C, Wang Y, Yuan X, Sun G, Shen B, Xu F, Fan G, Jin M, Li X, Liu G. Berberine inhibits lipopolysaccharide-induced expression of inflammatory cytokines by suppressing TLR4-mediated NF-ĸB and MAPK signaling pathways in rumen epithelial cells of Holstein calves. J Dairy Res. 2019, 86(2):171-176.

[54] Zhu Y, Guan Y, Loor JJ, Sha X, Coleman DN, Zhang C, Du X, Shi Z, Li X, Wang Z, Liu G, Li X. Fatty acid-induced endoplasmic reticulum stress promoted lipid accumulation in calf hepatocytes, and endoplasmic reticulum stress existed in the liver of severe fatty liver cows. J Dairy Sci. 2019, 102(8):7359-7370

[53] Xu Q, Li X, Ma L, Loor JJ, Coleman DN, Jia H, Liu G, Xu C, Wang Y, Li X. Adipose tissue proteomic analysis in ketotic or healthy Holstein cows in early lactation. J Anim Sci. 2019, 97(7):2837-2849

[52] Sun X, Li X, Jia H, Loor JJ, Bucktrout R, Xu Q, Wang Y, Shu X, Dong J, Zuo R, Yang L, Liu G, Li X. Effect of heat-shock protein B7 on oxidative stress in adipocytes from preruminant calves. J Dairy Sci. 2019, 1026):5673-5685

[51] Peng Z, Li X, Wang Z, Liu G, Li X. The effects of non-esterified fatty acids and β-hydroxybutyrate on the hepatic CYP2E1 in cows with clinical ketosis. J Dairy Res. 2019 86(1):68-72

[50] Xudong Sun, Xiaobing Li, Hongdou Jia, Juan J. Loor&, Ryan Bucktrout&, Qiushi Xu, Yazhe Wang, Xin Shu, Jihong Dong, Rankun Zuo, Liangyu Yang, Guowen Liu, and Xinwei Li. Effect of heat-shock protein b7 on oxidative stress in adipocytes from pre-ruminant calves. J Dairy Sci. 2019 [Epub ahead of print]

[49] Sun X, Wang Y, Loor JJ, Bucktrout R, Shu X, Jia H, Dong J, Zuo R, Liu G, Li X, Li X*. High expression of cell death-inducing DFFA-like effector a (CIDEA) promotes milk fat content in dairy cows with clinical ketosis. J Dairy Sci. 2018 Dec 26. pii: S0022-0302(18)31135-4. doi: 10.3168/jds.2018-15439. [Epub ahead of print]

[48] Zhao C, Wang Y, Peng Z, Sun X, Sun G, Yuan X, Li X*, Liu G. Subacute ruminal acidosis suppressed the expression of MCT1 in rumen of cows. J Cell Physiol. 2018 Dec 7. doi: 10.1002/jcp.27829. [Epub ahead of print]

[47] Li Y, Ding H, Dong J, Ur Rahman S, Feng S, Wang X, Wu J, Wang Z, Liu G, Li X, Li X*. Glucagon attenuates lipid accumulation in cow hepatocytes through AMPK signaling pathway activation. J Cell Physiol. 2018 Nov 27. doi: 10.1002/jcp.27258. [Epub ahead of print]

[46] Zhu Yiwei, Liu Guowen, Du Xiliang, Shi Zhen, Jin Meiyu, Sha Xueying, Li Xiaobing, Wang Zhe, Li Xinwei*. Expression patterns of hepatic genes involved in lipid metabolism in cows with subclinical or clinical ketosis. Journal of dairy science. 2018 Nov 21, DOI:10.3168/jds.2018-14965[Epub ahead of print]

[45] Jia H, Li X, Liu G, Loor JJ, Buctrout R, Sun X, Li G, Shu X, Dong J, Wang Y, Zuo R, Wang Z, Li X*. Perilipin 5 promotes hepatic steatosis in dairy cows through increasing lipid synthesis and decreasing very-low-density lipoprotein assembly. J Dairy Sci. 2019, 102:833–845

[44] Peng Z, Li X, Xing D, Du X, Wang Z, Liu G, Li X*. Nobiletin alleviates palmitic acidinduced NLRP3 inflammasome activation in a sirtuin 1dependent manner in AML12 cells. Mol Med Rep, 2018, 18(6): 5815-5822.

[43] Du X, Liu G, Loor JJ, Fang Z, Bucktrout R, Yang Y, Ye Q, Shi Z, Shen T, Wang X, Peng Z, Zhao C, Lv B, Xing D, Zhu Y, Li X, Li X*. Impaired hepatic autophagic activity in dairy cows with severe fatty liver is associated with inflammation and reduced liver function. J Dairy Sci. 2018, 101:11175–11185

[42] Du X, Shen T, Wang H, Qin X, Xing D, Ye Q, Shi Z, Fang Z, Zhu Y, Yang Y, Peng Z, Zhao C, Lv B, Li X, Liu G, Li X*. Adaptations of hepatic lipid metabolism and mitochondria in dairy cows with mild fatty liver. J Dairy Sci. 2018, 101(10):9544-9558.

[41] Zhang Y, Li X, Zhang H, Zhao Z, Peng Z, Wang Z, Liu G, Li X*. Non-Esterified Fatty Acids Over-Activate the TLR2/4-NF-Κb Signaling Pathway to Increase Inflammatory Cytokine Synthesis in Neutrophils from Ketotic Cows. Cell Physiol Biochem. 2018; 48(2):827-837.  5.5

[40] Zhen Shi, Xiao-Bing Li, Zhi-Cheng Peng, Shou-Peng Fu, Chen-Xu Zhao, Xi-Liang Du, Zhi-Yuan Fang, Zhe Wang, Guo-Wen Liu, Xin-Wei Li*. Berberine Protects against NEFA-Induced Impairment of Mitochondrial Respiratory Chain Function and Insulin Signaling in Bovine Hepatocytes. Int. J. Mol. Sci. 2018, 19, 1691.  3.687

[39] Xinwei Li, Yu Li, Hongyan Ding, Jihong Dong, Renhe Zhang, Dan Huang, Lin Lei, Zhe Wang, Guowen Liu and Xiaobing Li. Insulin suppresses the AMPK signaling pathway to regulate lipid metabolism in primary cultured hepatocytes of dairy cows. Journal of Dairy Research (2018) 85 157–162.  1.17

[38] Yang X, Yu K, Wang H, Zhang H, Bai C, Song M, Han Y, Shao B, Li Y, Li X. Bone impairment caused by AlCl3 is associated with activation of the JNK apoptotic pathway mediated by oxidative stress. Food Chem Toxicol. 2018; 116(Pt B):307-314.  3.977

[37] Chenxu Zhao, Guowen Liu, Xiaobing Li, Yuan Guan, Yazhou Wang, Xue Yuan, Guoquan Sun, Zhe Wang, Xinwei Li. Inflammatory mechanism of Rumenitis in dairy cows with subacute ruminal acidosis. BMC Veterinary Research, 2018, 14:135.  1.958

[36] Wenwen Gao, Xiliang Du, Lin Lei, Heyuan Wang, Min Zhang, Zhe Wang, Xiaobing Li, Guowen Liu, Xinwei Li. NEFA induced ROS impaired insulin signalling through the JNK and p38MAPK pathways in non-alcoholic steatohepatitis. J Cell Mol Med. 2018;22:3408–3422  4.302

[35] Zhang S, Liu G, Xu C, Liu L, Zhang Q, Xu Q, Jia H, Li X and Li X. Perilipin 1 Mediates Lipid Metabolism Homeostasis and Inhibits Inflammatory Cytokine Synthesis in Bovine Adipocytes. Front. Immunol. 2018, 9:467  5.511

[34] Li XW, Xu QS, Zhang RH, Yang W, Li Y, Zhang YM, Tian Y, Zhang M, Wang Z, Liu GW, Xia C, Li XB. Ultrasonographic findings in cows with left displacement of abomasum, before and after reposition surgery. BMC Vet Res. 2018 Feb 12;14(1):44

[33] Du, X., Y. Zhu, Z. Peng, Y. Cui, Q. Zhang, Z. Shi, Y. Guan, X. Sha, T. Shen, Y. Yang, X. Li, Z. Wang, X. Li, and G. Liu. High concentrations of fatty acids and beta-hydroxybutyrate impair the growth hormone-mediated hepatic JAK2-STAT5 pathway in clinically ketotic cows. Journal of Dairy Science. 2018, 101(4):3476-3487

[32] Xiliang Du, Xiaobing Li, Liang Chen, Min Zhan, Lin Lei, Wenwen Gao, Zhen Shi, Yuhao Dong, Zhe Wang, Xinwei Li*, Guowen Liu*. Hepatic miR-125b inhibits insulin signaling pathway by targeting PIK3CD. J Cell Physiol. 2018, 233(8):6052-6066

[31] Xiliang Du, Yuchen Yang, Chuang Xu, Zhicheng Peng, Min Zhang, Lin Lei, Wenwen Gao, Yuhao Dong, Zhen Shi, Xudong Sun, Zhe Wang, Xiaobing Li, Xinwei Li, Guowen Liu. Upregulation of miR-181a impairs hepatic glucose and lipid homeostasis. Oncotarget. 2017, 8(53): 9136291378

[30] Xiliang Du, Liang Chen, Dan Huang, Zhicheng Peng, Chenxu Zhao, Yuming Zhang,Yiwei Zhu, Zhe Wang, Xinwei Li, Guowen Liu. Elevated Apoptosis in the Liver of Dairy Cows with Ketosis. Cell Physiol Biochem 2017;43:568-578

[29] Xudong Sun, Xue Yuan, Liang Chen, Tingting Wang, Zhe Wang, Guoquan Sun, Xiaobing Li, Xinwei Li, Guowen Liu. Histamine Induces Bovine Rumen Epithelial Cell Inflammatory Response via NF-κB Pathway. Cellular Physiology and Biochemistry, 2017, 42(3):1109-1119

[28] Xiliang Du, Zhen Shi, Zhicheng Peng, Chenxu Zhao, Yuming Zhang, Zhe Wang, Xiaobing Li, Guowen Liu*, Xinwei Li*. Acetoacetate induces hepatocytes apoptosis by the ROS-mediated MAPKs pathway in ketotic cows. J Cell Physiol. 2017, 232:32963308

[27] Song Y, Li N, Gu J, Fu S, Peng Z, Zhao C, Zhang Y, Li X, Wang Z, Li X, Liu G.β  

-Hydroxybutyrate induces bovine hepatocyte apoptosis via an ROS-p38 signaling

pathway. J Dairy Sci. 2016, 99(11):9184-9198.

[26] Xiaoxia Shi, Dangdang Li, Qinghua Deng, Zhicheng Peng, Chenxu Zhao, Xiaobing Li, Zhe Wang, Xinwei Li* and Guowen Liu*. Acetoacetic acid induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes. Journal of Dairy Research, 2016, 83: 442-446

[25] Li Y, Ding HY, Wang XC, Feng SB, Li XB, Wang Z, Liu GW, Li XW. An association between the level of oxidative stress and the concentrations of NEFA and BHBA in the plasma of ketotic dairy cows. J Anim Physiol Anim Nutr (Berl). 2016, 100(5):844-851.

[24] Lin Lei, Yiwei Zhu, Wenwen Gao , Xiliang Du, Min Zhang, Zhicheng Peng, Xiaobing Li, ZheWang, Xinwei Li*, Guowen Liu. Alpha-lipoic acid attenuates endoplasmic reticulum stress-induced insulin resistance by improving mitochondrial function in HepG2 cells. Cellular Signalling, 2016, 281441-1450

[23] Q. Deng, Z. Shi, W. Huang, X. Du, W. Gao, X. Zhu, L. Lei, M. Zhang, G. Sun, X. Yuan, X. Li, Z. Wang, G. Liu, X. Li. Effects of b-hydroxybutyricacid on the synthesis and assembly of very low-density lipoprotein in bovine hepatocytes in vitro. J Anim Physiol Anim Nutr. 2016, 100(2):331-6.

[22] Yu Li, Hongyan Ding, Xichun Wang, Lei Liu, Dan Huang, Renhe Zhang, Lihui Guo, Zhe Wang, Xiaobing Li, Guowen Liu, Jinjie Wu and Xinwei Li. High levels of acetoacetate and glucose increase expression of cytokines in bovine hepatocytes, through activation of the NF-κB signalling pathway. Journal of Dairy Research, 2016, 83:5157.

[21] Xinwei Li, Yuan Guan, Ying Li, Dianjun Wu, Lei Liu, Xiaobing Li, Zhe Wang, Qinghua Deng, Liu Guowen. Effects of insulin-like growth factor-1 on the assembly and secretion of very low-density lipoproteins in cow hepatocytes in vitro. General and Comparative Endocrinology, 2016, 226:8287 [20]Min Zhang, Shiqi Zhang, Qi Hui, Lin Lei, Xiliang Du, Wenwen Gao, Renhe Zhang, Guowen Liu, Xiaobing Li, Xinwei Li. β-Hydroxybutyrate Facilitates Fatty Acids Synthesis Mediated by Sterol Regulatory Element-Binding Protein1 in Bovine Mammary Epithelial Cells. Cell Physiol Biochem 2015;37:2115-2124

[17] Yin L, X Qin, Q Deng, Y Zhang, L Lei, W Gao, Z Peng, X Du, G Liu and X Li. The isolation of pre-adipocytes from dairy cow adipose tissue and the development of pre-adipocytes into mature adipocytes. Pak Vet J, 2015, 35(3): 283-288

[18] Xinwei Li, Weikun Huang, Jingmin Gu, Xiliang Du, Lin Lei, Xue Yuan, Guoquan Sun, Zhe Wang, Xiaobing Li, Guowen Liu.SREBP-1c overactivates ROS-mediated hepatic NF-κB inflammatory pathway in dairy cows with fatty liver. Cellular Signalling, 2015, 27:20992109

[19] Qinghua Deng, Guowen Liu, Lei Liu, Yuming Zhang, Liheng Yin, Xiaoxia Shi, Jianguo Wang, Xue Yuan, Guoquan Sun, Yu Li, Wei Yang, Lihui Guo, Renhe Zhang, Zhe Wang, Xiaobing Li and Xinwei Li. BHBA Influences Bovine Hepatic Lipid Metabolism via AMPK Signaling Pathway. Journal of Cellular Biochemistry 2015,116 :10701079.

[16] Xiaoxia Shi, Dangdang Li, Qinghua Deng, Yu Li, Guoquan Sun, Xu e Yuan, Yuxiang Song, Zhe   Wang, Xiaobing Li, Xinwei Li, Guowen Liu. NEFAs activate the oxidative stress-mediated NF-kB signaling pathway to induce inflammatory response in calf hepatocytes. Journal of Steroid Biochemistry & Molecular Biology, 2015, 145:103-112.

[15] Xinwei Li, Yu Li, Wentao Yang, Chong Xiao, Shixin Fu, Qinghua Deng, Hongyan Ding, Zhe Wang, Guowen Liu, Xiaobing Li. 2014. SREBP-1c  overexpression  induces  triglycerides  accumulation  through increasing  lipid  synthesis  and  decreasing  lipid  oxidation  and  VLDL assembly  in  bovine  hepatocytes. Journal of Steroid Biochemistry & Molecular Biology, 143:174-182.

[14] Wei Yang, Dian-Jun Wu, Ren-He Zhang, Qing-Hua Deng, Hong-Yan Ding, Yu Tian, Min Zhang, Guo-Wen Liu, Zhe Wang, Xiao-Bing Li and Xin-Wei Li. 2014. Effects of Propylthiouracil-Induced Hypothyroidism on Nonalcoholic Fatty Liver Disease in Rats Fed a High-Fat and High-Cholesterol Diet. Pakistan Veterinary Journal.

[13] Yuxiang Song1, Xinwei Li1, Yu Li, Na Li,Xiaoxia Shi, Hongyan Ding, Yuhang Zhang, Xiaobing Li, Guowen Liu, Zhe Wang. 2014. Non-esterified fatty acids activate the ROSp38p53/Nrf2 signaling pathway to induce bovine hepatocyte apoptosis in vitro. Apoptosis, 19:984-997.

[12] Qinghua Deng1, Xinwei Li1, Shixin Fu, Liheng Yin, Yuming Zhang, Tingting Wang, Jianguo Wang, Lei Liu, Xue Yuan, Guoquan Sun, Zhe Wang, Guowen Liu, Xiaobing Li. 2014. SREBP-1c Gene Silencing can Decrease Lipid Deposits in Bovine Hepatocytes Cultured in Vitro. Cell Physiol Biochem, 33:1568-1578

[11] Xiaoxia Shi1, Xinwei Li1, Dangdang Li, Yu Li, Yuxiang Song, Qinghua Deng, Jianguo Wang, Yuhang Zhang, Hongyan Ding, Liheng Yin, Yuming Zhang, Zhe Wang, Xiaobing Li, Guowen Liu. 2014. β-Hydroxybutyrate Activates the NF-κB Signaling Pathway to Promote the Expression of Pro-Inflammatory Factors in Calf Hepatocytes. Cell Physiol Biochem, 33:920-932

[10] Lei Liu1, Xinwei Li1, Yu Li1, Yuan Guan, Yuxiang  Song, Liheng Yin, Hui Chen, Liancheng Lei, Juxiong Liu, Xiaobing Li, Zhe Wang, Xiaoyu Yang, and Guowen Liu. 2014. Effects of nonesterified fatty acids on the synthesis and assembly of very low density lipoprotein in bovine hepatocytes in vitro. J. Dairy Sci. 97 :13281335

[9] Hui Chen1, Liang Zhang1, Xinwei Li1, Xiaobing Li1, Liancheng Lei, Juxiong Liu, Qinghua Deng, Jianguo Wang, Zhaoxi Liu, Wentao Yang, Zhe Wang, Hui Zhang*, Guowen Liu*. 2013. Adiponectin activates the AMPK signaling pathway to regulate lipid metabolism in bovine hepatocytes. J Steroid Biochem Mol Biol, 138:445-454.

[8] Yuan Guan1, Xinwei Li1, Xin Zhang, Yunyun Cheng, Dan Su, Chao Lu, Xibi Fang, Qiang Ma, Dawei Zhang, Hao Yu, Linlin Hao, Songcai Liu. Controlled delivery of growth hormone-releasing peptide 6 from the poly (lactic-co-glycolic acid)-poly (ethylene glycol)-poly (lactic-co-glycolic acid) copolymer and the effect of a growth hormone-releasing peptide 6-copolymer hydrogel on the growth of rex rabbits. Journal of Applied Polymer Science, 2013, 131(9):4458-4466.

[7] Xinwei Li, Hui Chen, Yuan Guan, Xiaobing Li, Liancheng Lei, Juxiong Liu, Liheng Yin, Guowen Liu,Zhe Wang. 2013. Acetic Acid Activates the AMP-Activated Protein Kinase Signaling Pathway to Regulate Lipid Metabolism in Bovine Hepatocytes. PLOS ONE, 8: e67880

[6] Xinwei Li, Xiaobing Li, Hui Chen, Liancheng Lei, Juxiong Liu, Yuan Guan, Zhaoxi Liu, Liang Zhang, Wentao Yang, Chenxu Zhao, Shixin Fu, Peng Li, Guowen Liu, Zhe Wang. 2013. Non-Esterified Fatty Acids Activate the AMP-Activated Protein Kinase Signaling Pathway to Regulate Lipid Metabolism in Bovine Hepatocytes. Cell Biochem Biophys, 67:11571169.

[5] Xinwei Li, Yuan Guan, Xiaoxia Shi, Hongyan Ding, Yuxiang Song, Chenggang Li, Rong Liu, Guowen Liu. 2013. Effects of High Zinc Levels on the Lipid Synthesisin Rat Hepatocytes. Biol Trace Elem Res, 154:97-102

[4] Xinwei Li, Xiaobing Li, Ge Bai, Hui Chen, Qinghua Deng, Zhaoxi Liu, Liang Zhang, Guowen Liu, Zhe Wang. 2012. Effects of non-esterified fatty acids on the gluconeogenesis in bovine hepatocytes. Mol Cell Biochem, 359:385388.

[3] Xinwei Li, Yanfei Han, Yuan Guan, Liang Zhang, Chongsheng Bai, Yanfei Li. 2012. Aluminum Induces Osteoblast Apoptosis Through the OxidativeStress-Mediated JNK Signaling Pathway. Biol Trace Elem Res, 150:502508

[2] Xinwei Li,Chongwei Hu,Yanzhu Zhu,Hao Sun, Yanfei Li, Zhigang Zhang. 2011. Effects of Aluminum Exposure on Bone Mineral Density,Mineral, and Trace Elements in Rats. Biol Trace Elem Res, 143:378385

[1] Xinwei Li, Lichao Zhang, Yanzhu Zhu, Yanfei Li. 2011. Dynamic analysis of exposure to aluminum and an acidic condition on bone formation in young growing rats. Environmental toxicology and pharmacology, 31:295301

著作教材:

《兽医内科学》、《动物疾病病理诊断学》、《兽医临床诊断学》、《动物普通病学》

获奖情况:

美国乳业协会颁发的最具影响力论文奖

吉林省青年科技奖

吉林省自然科学学术成果二等奖

吉林省自然科学学术成果三等奖

社会兼职

Journal of Dairy Science学术编委

Journal of Dairy Research学术编委

Universal Journal of Pharmaceutical research学术编委

Journal of Veterinary Science and Research学术编委

BBA, J Dairy SciencePlos ONECellular Physiology and BiochemistryMolecular and Cellular Biochemistry, Cellular Signalling, BIOL TRACE ELEM RESVet J30多个杂志审稿人

中国兽医内科及诊疗分会常务理事,美国ADSA协会会员