朱冠教授

来源: 发稿时间:2021-07-15 浏览次数:

姓名:

朱冠

职称:

教授

硕导/博导:

博导

最高学位:

博士

最高学历:

研究生、博士后

办公电话:

电子邮箱:

zhuguan@jlu.edu.cn

cryptosporida@gmail.com

 

详细情况

学科专业:

兽医公共卫生学

研究方向:

人兽共患寄生虫学(隐孢子虫、球虫、贾第鞭毛虫等);寄生病原生物学、生物化学、基因组学、药靶和药物、分子互作等

讲授课程:

本科:新生研讨课(Critical thinking讨论)

教育经历:

1979 – 1983

1983 – 1986

1989 – 1993

中国

中国

美国

杭州大学 生物学 学士

杭州大学 原生动物学/寄生虫学  硕士

佐治亚大学 禽类生物学/寄生虫学  博士

工作经历:

1994 – 2000

2000 – 2005

2005 – 2010

2010 – 2017

2017 – 至今

美国

美国

美国

美国

中国

纽约州Wadsworth中心 博士后(94-96)、研究员(96-00)

德克萨斯A&M大学 兽医学院   助理教授

德克萨斯A&M大学 兽医学院   副教授

德克萨斯A&M大学 兽医学院   教授

吉林大学 人兽共患病研究所   国家级特聘教授

学术论文:

详情请参见: https://www.researchgate.net/profile/Guan-Zhu

10代表性论文(总100多篇)

1. Zhang T., Gao X, Wang D, Zhao J, Zhang N, Li Q, Zhu G*, Yin J* (2021) A Single-Pass Type I Membrane Protein from the Apicomplexan Parasite Cryptosporidium parvum with Nanomolar Binding Affinity to Host Cell Surface. Microorganisms. 9:1015. Doi:10.3390/microorganisms9051015

2. Zhu G*, Yin J, Cuny GD (2021) Current status and challenges in drug discovery against the globally important zoonotic cryptosporidiosis. Animal Diseases. 1:3. Doi: 10.1186/s44149-021-00002-y

3. Liu M, Zhu G (2020) An old drug as a promising new cure for the hard-to-treat echinococcosis. EBioMedicine (Lancet publisher). 55:102749. PMCID: PMC7184152

4. Ma J, Zhang H, Jin Z, Guo F, Geng M, Ju M, Ravichandran A, Orugunty R, Smith L* & Zhu G* (2020) Novel antiparasitic activity of the antifungal lead occidiofungin. Antimicrobial Agents & Chemotherapy. 64(8):e00244-20. PMID: 32457108

5. Yu X, Guo F, Mouneimne RB & Zhu G (2020) Cryptosporidium parvum elongation factor 1α (CpEF1α) participates in the formation of base structure at the infection site during invasion. Journal of Infectious Diseases. 221(11):1816-1825. PMID: 31872225

6. Zhang H & Zhu G (2020). High-Throughput Screening of Drugs Against the Growth of Cryptosporidium parvum In Vitro by qRT-PCR. Methods in Molecular Biology. 2052:319-34. PMID: 31452170

7. Jin Z, Ma J, Zhu G* & Zhang H* (2019). Discovery of Novel Anti-cryptosporidial Activities From Natural Products by in vitro High-Throughput Phenotypic Screening. Frontiers in Microbiology. 10:1999. PMID: 31551955

8. Yu X, Hoyle RL, Guo F, Ratliff CM, Cantu V, Crow J, Xiang L, Heatley JJ & Zhu G (2019). A Vavraia-like microsporidium as the cause of deadly infection in threatened and endangered Eurycea salamanders in the United States. Parasites & Vectors. 12(1):108. PMID: 30871588

9. Guo F, Zhang H, Eltahan R & Zhu G (2019). Molecular and Biochemical Characterization of a Type II Thioesterase From the Zoonotic Protozoan Parasite Cryptosporidium parvum. Frontiers in Cellular & Infection Microbiology. 9:199. PMID: 31231619

10. Eltahan R, Guo F, Zhang H & Zhu G (2019). The Action of the Hexokinase Inhibitor 2-deoxy-d-glucose on Cryptosporidium parvum and the Discovery of Activities against the Parasite Hexokinase from Marketed Drugs. Journal of Eukaryotic Microbiology. 66(3):460-8. PMID: 30222231

11. Guo F, Zhang H, McNair NN, Mead JR & Zhu G (2018). The Existing Drug Vorinostat as a New Lead Against Cryptosporidiosis by Targeting the Parasite Histone Deacetylases. The Journal of Infectious Diseases. 217(7):1110-7. PMID: 29300993

12. Yu X, Zhang H, Zhu G. 2017. Characterization of host cell mutants significantly resistant to Cryptosporidium parvum infection. Journal of Eukaryotic Microbiology. 64(6):843-849. PMID: 28432811.

13. Wang S, Wang S, Luo Y, Xiao L, Luo X, Gao S, Dou Y, Zhang H, Guo A, Meng Q, Hou J, Zhang B, Zhang S, Yang M, Meng X, Mei H, Li H, He Z, Zhu X, Tan X, Zhu XQ, Yu J, Cai J, Zhu G*, Hu S* & Cai X* (2016). Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host. Nature Communications. 7:12845. PMID: 27653464

14. Ifeonu OO, Chibucos MC, Orvis J, Su Q, Elwin K, Guo F, Zhang H, Xiao L, Sun M, Chalmers RM, Fraser CM, Zhu G, Kissinger JC, Widmer G & Silva JC (2016). Annotated draft genome sequences of three species of Cryptosporidium: Cryptosporidium meleagridis isolate UKMEL1, C. baileyi isolate TAMU-09Q1 and C. hominis isolates TU502_2012 and UKH1. Pathogens & Diseases. 74(7). PMID: 27519257

15. Xiang L, Guo F, Yu Y, Parson LS, LaCoste L, Gibson A, Presley SM, Peterson M, Craig TM, Rollins D, Fedynich AM & Zhu G (2016). Multi-Year Survey of Coccidia, Cryptosporidia, Microsporidia, Histomona and Hematozoa in Wild Quail in the Rolling Plains Ecoregion of Texas and Oklahoma, USA. Journal of Eukaryotic Microbiology. PMID: 27222431

16. Zhang H, Guo F & Zhu G (2015). Cryptosporidium Lactate Dehydrogenase Is Associated with the Parasitophorous Vacuole Membrane and Is a Potential Target for Developing Therapeutics. PLoS Pathogens. 11(11):e1005250. PMID: 26562790

17. Guo F, Ortega-Pierres G, Arguello-Garcia R, Zhang H & Zhu G (2015). Giardia fatty acyl-CoA synthetases as potential drug targets. Frontiers in Microbiology. 6:753. PMID: 26257723

18. Checkley W, White AC, Jr., Jaganath D, Arrowood MJ, Chalmers RM, Chen XM, Fayer R, Griffiths JK, Guerrant RL, Hedstrom L, Huston CD, Kotloff KL, Kang G, Mead JR, Miller M, Petri WA, Jr., Priest JW, Roos DS, Striepen B, Thompson RC, Ward HD, Van Voorhis WA, Xiao L, Zhu G & Houpt ER (2015). A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium. Lancet Infectious Diseases. 15(1):85-94. PMID: 25278220

19. Yu Y, Zhang H, Guo F, Sun M & Zhu G (2014). A unique hexokinase in Cryptosporidium parvum, an apicomplexan pathogen lacking the Krebs cycle and oxidative phosphorylation. Protist. 165(5):701-14. PMID: 25216472

20. Guo F, Zhang H, Fritzler JM, Rider SD, Jr., Xiang L, McNair NN, Mead JR & Zhu G (2014). Amelioration of Cryptosporidium parvum infection in vitro and in vivo by targeting parasite fatty acyl-coenzyme A synthetases. Journal of Infectious Diseases. 209(8):1279-87. PMID: 24273180;  PMC3969544.

21. Xiang L, Guo F, Zhang H, LaCoste L, Rollins D, Bruno A, Fedynich AM & Zhu G (2013). Gene discovery, evolutionary affinity and molecular detection of Oxyspirura petrowi, an eye worm parasite of game birds. BMC Microbiology. 13:233. PMID: 24144118;  PMC4015439

22. Zhang H, Guo F, Zhou H & Zhu G (2012). Transcriptome analysis reveals unique metabolic features in the Cryptosporidium parvum Oocysts associated with environmental survival and stresses. BMC Genomics. 13:647. PMID: 23171372;  PMC3542205

23. Fritzler JM & Zhu G (2012). Novel anti-Cryptosporidium activity of known drugs identified by high-throughput screening against parasite fatty acyl-CoA binding protein (ACBP). Journal of Antimicrobial Chemotherapy. 67(3):609-17. PMID: 22167242;  PMC3276058.

24. Fritzler JM, Craig TM, Elgayar A, Plummer C, Wilson RS, Peterson MJ & Zhu G (2011). A new eimeriid (Apicomplexa) species from endangered Attwater's prairie chickens (Tympanuchus cupido attwateri) in Texas. Journal of Parasitology. 97(4):671-5. PMID: 21506827.

25. Zhu G, Shi X & Cai X (2010). The reductase domain in a Type I fatty acid synthase from the apicomplexan Cryptosporidium parvum: restricted substrate preference towards very long chain fatty acyl thioesters. BMC Biochemistry. 11:46. PMID: 21092192;  PMC2995488

26. Yu Y, Zhang H & Zhu G (2010). Plant-type trehalose synthetic pathway in cryptosporidium and some other apicomplexans. PLoS One. 5(9):e12593. PMID: 20830297;  PMC2935371

27. Templeton TJ, Enomoto S, Chen WJ, Huang CG, Lancto CA, Abrahamsen MS & Zhu G (2010). A genome-sequence survey for Ascogregarina taiwanensis supports evolutionary affiliation but metabolic diversity between a Gregarine and Cryptosporidium. Molecular Biology and Evolution. 27(2):235-48. PMID: 19778951;  PMC2877549.

28. Rider SD, Jr. & Zhu G (2010). Cryptosporidium: genomic and biochemical features. Experimental Parasitology. 124(1):2-9. PMID: 19187778;  PMC2819285

29. Lei C, Rider SD, Jr., Wang C, Zhang H, Tan X & Zhu G (2010). The apicomplexan Cryptosporidium parvum possesses a single mitochondrial-type ferredoxin and ferredoxin:NADP+ reductase system. Protein Science. 19(11):2073-84. PMID: 20737579;  PMC3005779

获奖情况:

2017 硕腾兽医研究优秀奖(Zoetis Award for Veterinary Research Excellence

2000 国际原生动物学会Hutner青年科学家奖(Seymour Hutner Young Scientist Award

学术兼职:

中国畜牧兽医学会 兽医寄生虫学分会理事中国动物学会 寄生虫学专业委员会理事中国动物学会 原生动物学专业委员会理事;杂志编委:ZoonosesFrontiers in MicrobiologyBMC MicrobiologyAnimal DiseasesJournal of Eukaryotic Microbiologyreview board);Pathogens (Topics Board)中国兽医学报。国际数据库:CryptoDB专家委员会