本科生：自然疫源性疾病、动物流行病学、人兽共患病学

研究生：兽医流行病学进展

动物重大疫病及人兽共患病发病机制及病原结构与功能分析

新城疫病毒感染细胞分泌的外泌体（NDV Ex）相关研究，通过分析外泌体及其组分调控NDV增殖的机制，以及研究外泌体对禽类天然免疫识别与应答的调控机制，认识新城疫病毒感染条件下外泌体的作用模式。

新城疫病毒样颗粒（NDV VLPs）相关研究，利用杆状病毒表达系统（Bac to Bac）构建以新城疫病毒NA-1株M蛋白为骨架的多种嵌合VLPs，通过研究其在体内体外活化树突状细胞的能力及相应信号通路，评价其在天然免疫中的作用，并通过小鼠及SPF鸡免疫攻毒实验评估NDV VLP作为疫苗的效果、其自佐剂效应及其作为外源蛋白展示平台的应用潜能。

新城疫病毒反向遗传系统相关研究，通过本实验建立的基于NDV NA-1株的，以CMV为启动子，利用RNA聚合酶II的NDV反向遗传操作系统，对NDVNA-1株进行改造，以构建致弱或表达外源蛋白的NA-1毒株，评价其作为疫苗候选株的应用价值。

2007.09～2012.07 就读于中国农业大学，动物医学学院动物医学专业，获得农学学士学位。

2012.10～2014.07 就读于UK Royal Agricultral University，获得Degree of Master of Science，导师Prof.Meriel Moore-Colyer。

2016.09～2019.06 就读于吉林大学，动物医学学院，预防兽医学方向动物传染病专业获得农学博士学位，导师丁壮教授。

2019.07~2021.9 师资博士后，吉林大学，基础医学院博士后工作站，预防医学方向，合作导师金宁一院士

2021.9~2023.3 讲师，吉林大学动物医学学院

2023.3~至今 副教授，吉林大学动物医学学院

1、Xiaohong Xu, Jiaxin Ding, Jindou Li, Cong Xue, Jianzhong Wang, Yanlong Cong, Renfu Yin, Mingxi Yang, Jing Qian,Zhuang Ding*,Evaluation of the safety and protection efficacy of an attenuated genotype VIINewcastle disease virusstrain as a candidate vaccine.Microb Pathog, 2020, 139: 103831.(IF=2.581,JCR分类4区)

2、Xiaohong Xu,Jiaxin Ding, Jing Qian, Lingsong Qin, Jindou Li, Cong Xue, Weiqi Wang, Wei Ding, Renfu Yin*,Ningyi Jin*,Zhuang Ding*,ChimericNewcastle disease virus-like particles containing DC-binding peptide-fused haemagglutininprotect chickens from virulent Newcastle disease virus and H9N2 avian influenza virus challenge.Virol Sin, 2020, 35:455–467(IF=3.242,JCR分类3区)

3、Xiaohong Xu,Zhuang Ding, Jindou Li, Jiaming Liang, Zhaoyang Bu, Jiaxin Ding, Yanling Yang, Xulong Lang, Xinglong Wang, Renfu Yin, Jing Qian,Newcastle disease virus-like particles containing the Brucella BCSP31 protein induce dendritic cell activation and protect mice against virulent Brucella challenge [J].Vet Microbiol.2019, 229:39-47.(IF=2.572, JCR分类1区)

4、Xiaohong Xu, Jing Qian, Jiaxin Ding, Jindou Li, Fulong Nan, Weiqi Wang, Qi Qin, Yidong Fei, Cong Xue, Jianzhong Wang, Renfu Yin,Zhuang Ding*,Detection of viral components in exosomes derived from NDV-infected DF-1 cells and their promoting ability invirus replication [J].Microb Pathog.2019, 128: 414-422.(IF=2.076, JCR分类4区)

5、Xiaohong Xu, Cong Xue, Xinxin Liu, Junjiao Li, Yidong Fei, Zhe Liu, Jiaqi Mu, Yuhai Bi, Jing Qian, Renfu Yin,Zhuang Ding*, A novel recombinant attenuatedNewcastle disease virusexpressing H9 subtype hemagglutinin protected chickens from challenge by genotype VII virulent Newcastle disease virus and H9N2 avian influenza virus [J].Vet Microbiol.2019,228:173-180.(IF=2.572, JCR分类1区)

6、Xiaohong Xu,Zhuang Ding,Qianliang Yuan, Jiaxin Ding, Jindou Li, Weiqi Wang, Yanlong Cong, Wei Ouyang, Yongshan Wang, Jing Qian, Renfu Yin, A genotype VIINewcastle disease virus-like particles confer full protection with reduced virus load and decreasedvirus shedding [J].Vaccine.2019,37(3):444-451.(IF=3.311, JCR分类3区)

7、Jing Qian,Xiaohong Xu(共同第一), Jiaxin Ding, Renfu Yin, Yixue Sun, Cong Xue, Jianzhong Wang, Chan Ding, Shengqing Yu, Xiufan Liu, Shunlin Hu, Chunfeng Wang, Yanlong Cong,Zhuang Ding*.Newcastle disease virus-like particles induce DC maturation through TLR4/NF-kB pathway and facilitate DC migration by CCR7-CCL19/CCL21 axis[J].Vet Microbiol,2017, 203:158-166.(IF=2.572, JCR分类1区)

8、Cong Xue,Xiaohong Xu(共同第一), Renfu Yin, Jing Qian, Yixue Sun, Chunfeng Wang, Chan Ding, Shengqing Yu, Shunlin Hu, Xiufan Liu, Yanlong Cong,Zhuang Ding*.Identification and pathotypical analysis of a novel VIk sub-genotypeNewcastle disease virusobtained from pigeon in China.Virus Res.2017,238:1-7.(IF=2.546, JCR分区3区)

9、Yixue Sun, Jing Qian,Xiaohong Xu, Yubo Tang, Wenzhang Xu, Wentao Yang, Yanlong Jiang, Guilian Yang, Zhuang Ding, Yanlong Cong, Chunfeng Wang. Dendritic cell-targeted recombinant Lactobacilli induce DC activation and T elicit specific immune responses against G57 genotype of avian H9N2 influenza virus infection [J]. Vet Microbiol. 2018, 223:9-20.(IF=2.572, JCR分类1区)

10、Jing Qian, Jiaxin Ding, Renfu Yin, Yixue Sun, Cong Xue,Xiaohong Xu, Jianzhong Wang, Chan Ding, Shengqing Yu, Xiufan Liu, Shunlin Hu, Yanlong Cong,Zhuang Ding*,Newcastle disease virus-likeparticles induce dendritic cell maturation and enhance viral-specific immune response [J].Virus Genes, 2017, 1-10.(IF=1.419, JCR分类4区)

11、Guanning Wei, Hongmei Sun, Haijun Wei, Tao Qin, Yifeng Yang,Xiaohong Xu, Shoujing Zhao*, Detecting the Mechanism behind the Transition from Fixed Two-Dimensional Patterned Sika Deer (Cervus nippon) Dermal Papilla Cells to Three-Dimensional Pattern[J].Int. J. Mol. Sci.2021,22, 4715.(IF = 4.556, JCR分类3区)

12、Xiaohong Xu, Di Zhang, Wei Ding, Weiqi Wang,Ningyi Jin*, Zhuang Ding*,NDV related exosome enhance NDV replication through exporting NLRX1 mRNA.Veterinary Microbiology 260 (2021) 10,https://doi.org/10.1016/j.vetmic.2021.1(IF = 2.791, JCR分类1区)

13、Di Zhang,Zhuang Ding *, Xiaohong Xu *，Pathologic mechanism of Newcastle disease viruse,viruses-2228057 , (IF=5.818, JCR分类1区)

14、Xibing Yu,Zhuang Ding*, Xiaohong Xu*,NDV inhibited IFN-βsecretion through impeding CHCHD10-mediated mitochondrial fusion to promote viral proliferation，Veterinary Microbiology，Veterinary Microbiology 290 (2024) 109973

15、Xibing Yu,Zhuang Ding*, Xiaohong Xu*, Mitochondrial protein CHCHD10 inhibits NDV replication and reduces pathological changes,Veterinary Microbiology，Veterinary Microbiology 290 (2024) 109986

16、丁伟,徐小洪(共同第一)等，poly(I:C)刺激鸡胚胎成纤维细胞产生外泌体的抗新城疫病毒活性[J].中国兽医学报,2018,38(06):1088-1093.

17、袁乾亮，徐小洪(4)等，基因Ⅶ型新城疫病毒样颗粒作为疫苗候选株的免疫效果.中国兽医学报, 2017 , 37 (2) :201-205

18、李金斗，徐小洪(4)等，GPI锚定蛋白介导嵌合新城疫病毒样颗粒的组装.中国兽医学报, 2017, 37 (6) :969-975

19、丁佳欣，徐小洪(3)等，新城疫病毒样颗粒对树突状细胞成熟的影响.中国兽医学报, 2017 , 37 (8) :1485-1489

1、秦岭松，徐小洪(3)等，嵌合NDV-HA病毒样颗粒的制备与鉴定，中国兽医学报, 2017 , 37 (7) :1237-1242

2、丁壮，徐小洪，钱晶，丁佳欣，李金斗，黄蕾，尹仁福.一种嵌合型新城疫病毒样颗粒的制备方法，国家发明专利授权号：ZL201611182622.6

3、丁壮，钱晶，丁佳欣，徐小洪，袁乾亮，武淑婷，尹仁福.一种新城疫病毒样颗粒、制备方法及其应用，国家发明专利授权号：ZL201611183096.5

4、丁壮，林洪哲，李金斗，丁佳欣，徐小洪，钱晶，尹仁福，丁伟.区分新城疫病毒样颗粒疫苗免疫血清与野毒感染血清的间接竞争ELISA方法及试剂盒，国家发明专利授权号：ZL201910449511.4

1、2017年吉林省研究生科技论文演讲比赛校内选拔赛，优秀奖。

2、2017中国畜牧兽医学会动物传染病学分会研讨会大会，优秀论文报告，三等奖。

3、吉林大学第七届中青年教师双语教学大赛三等奖（2022）

4、吉林大学第三届教师教学创新大赛二等奖（2023）

5、吉林大学动物医学学院“青年教师暨双语教学比赛”“双语组”一等奖（2022）