动物及人兽共患寄生虫病学，人兽共患寄生虫对宿主的调控机制，纳米抗体在寄生虫研究和诊断中的应用

本科生：动物寄生虫病学、人兽共患病学、寄生虫与人类健康

研究生：人兽共患病防控、微生物检测技术、病原微生物检测技术与规程

1. 2009年09月~2014年06月吉林大学动物医学学院动物医学专业，获农学学士学位

2. 2014年09月~2017年06月首都医科大学神经生物学专业，获理学硕士学位

3. 2019年09月~2025年01月 北京大学人体生理学专业，获理学博士学位

1.2018年08月~2019年08月 上海交通大学附属仁济医院，科研助理

2. 2025年12月至今 吉林大学唐敖庆青年学者，副教授

1. Zheng Y*, Jiang D*, Lu Y*, Zhang C*, Huang SM*, Lin H*, Zhang D*, Guo S*, Han J, Chen J, He Y, Zhang M, Gao Y, Guo Y, Wei R, Xia M, Qin Y, Liu Z, Yang F, Ge S, Yi F, Yu X, Lin H, Xiao P, Sun JP, Feng S. Development of an allosteric adhesion GPCR nanobody with therapeutic potential.Nat Chem Biol. 2025 Oct;21(10):1519-1530. doi: 10.1038/s41589-025-01896-2. Epub 2025 May 15. PMID: 40374856.

2. Guo L*, Cheng J*, Lian S*, Liu Q*, Lu Y*,Zheng Y*,Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP. Structural basis of amine odorant perception by a mammal olfactory receptor.Nature. 2023 Jun;618(7963):193-200. doi: 10.1038/s41586-023-06106-4. Epub 2023 May 24. PMID: 37225986.

3. Zheng Y,Zhang J, Huang M, Wang T, Qu X, Wu L, Song J, Wang W, Song Y, Yang C. Selection of Aptamers Against Vimentin for Isolation and Release of Circulating Tumor Cells Undergoing Epithelial Mesenchymal Transition.Anal Chem. 2020 Apr 7;92(7):5178-5184. doi: 10.1021/acs.analchem.9b05690. Epub 2020 Mar 18. PMID: 32148021.

4. Zheng Y, Qu J, Xue F, Zheng Y, Yang B, Chang Y, Yang H, Zhang J. Novel DNA Aptamers for Parkinson's Disease Treatment Inhibit α-Synuclein Aggregation and Facilitate its Degradation.Mol Ther Nucleic Acids. 2018 Jun 1;11:228-242. doi: 10.1016/j.omtn.2018.02.011. Epub 2018 Mar 6. PMID: 29858057; PMCID: PMC5992446.

5. Zheng Y, et al. Culture of Sika Deer Antler Perichondrium Cells and the Effects of SB-431542 on Its Proliferation.2012 International Conference on Biomedical Engineering and Biotechnology(EI).

6. Yang Z#, Wang JY#, Yang F#, Zhu KK#, Wang GP#, Guan Y#, Ning SL#, Lu Y, Li Y, Zhang C,Zheng Y, et al. Structure of GPR101-Gs enables identification of ligands with rejuvenating potential.Nat Chem Biol.2023 Nov 9.

7. Song J,Zheng Y,et al. A sequential multidimensional analysis algorithm for aptamer identification based on structure analysis and machine learning. Anal Chem. 2020 Feb 18;92(4):3307-3314.

8. Qu J, Yan H,Zheng Y, et al. The molecular mechanism of alpha-synuclein regulating the activity of protein phosphatase 2A. Cellular physiology and biochemistry; 2018,47 (6):2613

9. Qu J, Yu S,Zheng Y, et al. Aptamer and its applications in neurodegenerative diseases. Cell Mol LifeSci.2017 Feb; 74(4):683-695.