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  • 张西臣教授
  • 性别:男
  • 职称:教授
  • 硕导/博导:博导
  • 学科专业:预防兽医学
  • 最高学位:博士
  • 研究方向:动物及人兽共患寄生虫病学
  • 最高学历:研究生
  • 邮箱:xczhang@jlu.edu.cn

讲授课程

本科生:动物寄生虫病学

硕士生/博士生:论文写作指导、预防兽医学进展、兽医学进展、动物疫病防控学

教育经历

1979.09-1983.07:山东莱阳农学院牧医系兽医专业,本科生

1983.08-1986.07:解放军兽医大学兽医寄生虫学与寄生虫病学专业,硕士研究生

1988.08-1991.07:解放军兽医大学兽医寄生虫学与寄生虫病学专业,博士研究生

工作经历

1986.08-1988.07:济南军区军事医学研究所兽医检验室,助研

1991.08-1992.11:解放军农牧大学寄生虫学与寄生虫病学教研室,讲师

1992.12-1997.08:解放军农牧大学寄生虫学与寄生虫病学教研室,副教授

1997.09-1998.08:美国西南生物医学研究中心,访问学者

1997.09-至今:解放军农牧大学动物医学系/军需大学动物科技系/军事兽医系/吉林大学畜牧兽医学院/动物医学学院,教授

1998.11-至今:军需大学、吉林大学预防兽医学专业博士生导师

1999.12-2004.07:军需大学预防兽医学教研室/军事预防兽医学教研室,主任

2004.07-2017.02:吉林大学畜牧兽医学院副院长/吉林大学动物医学学院常务副院长

科研项目

近五年科研项目:

1.羊肝片吸虫病早期诊断双抗夹心ELISA和胶体金检测试剂盒的研制及其应用,吉林省科技厅重点研发项目,2020-2023,50万元;

2.微小隐孢子虫病毒(CSpV1)对微小隐孢子虫感染宿主天然免疫的影响,国家自然科学基金,2020-2023,58万元;

3.贾第虫端粒酶相关蛋白筛选及其在双核中的定位,国家自然科学基金,2017-2020,62万元;

4.宿主抗寄生虫感染先天免疫信号转导通路,973计划,2015-2019,294万元;

5.球虫类原虫病防控,农业部创新团队,2013-2017,100万元;

6.宠物疫病快速诊断和疫苗研究与师范—宠物弓形虫病、包虫病诊断方法建立与疫苗研究,国家公益性行业(农业)科研专项,2013-2017,100万元;

学术论文

近三年学术论文:

1.Cai, Y., Wang, X., Zhang, N., Li, J., Gong, P., He, B., Zhang, X., 2019. First report of the prevalence and genotype ofTrypanosoma spp. in bats in Yunnan Province, Southwestern China. Acta Trop198, 105105.

2.Fei, L., Zhengkai, W., Weina, J., Lili, C., Yuhang, G., Zhengtao, Y., Jianhua, L., Biao, Y., Xichen, Z., Pengtao, G., 2019.Trichomonas vaginalistriggers the release of THP-1 extracellular traps. Parasitology research118, 267-274.

3.Li, S., Gong, P., Zhang, N., Li, X., Tai, L., Wang, X., Yang, Z., Yang, J., Zhu, X., Zhang, X., Li, J., 2019. 14-3-3 Protein ofNeospora caninum Modulates Host Cell Innate Immunity Through the Activation of MAPK and NF-kappaB Pathways. Frontiers in microbiology10, 37.

4.Pan, L., Gong, P., Wang, X., Dong, J., Yang, J., Li, J., Zhang, X., 2019. The expressive identification and localization of bicoid-interacting protein 3 in theToxoplasma gondiiChinese I genotype Wh3 strain. Acta Trop197, 105040.

5.Tai, L., Li, J., Yin, J., Zhang, N., Yang, J., Li, H., Yang, Z., Gong, P., Zhang, X., 2019. A novel detection method ofCryptosporidium parvuminfection in cattle based onCryptosporidium parvumvirus 1. Acta biochimica et biophysica Sinica51, 104-111.

6.Wang, B., Zhang, N., Gong, P.T., Li, J., Yang, J., Zhang, X., Cai, K., 2019. Effect of temperature, pH, physical and chemical factors on germination rate of the chlamydospores of the nematophagous fungusDuddingtonia flagrans. FEMS microbiology letters366.

7.Wang, P., Gong, P., Wang, W., Li, J., Ai, Y., Zhang, X., 2019. AnEimeria acervulina OTU protease exhibits linkage-specific deubiquitinase activity. Parasitology research118, 47-55.

8.Wang, X., Gong, P., Zhang, N., Li, L., Chen, S., Jia, L., Liu, X., Li, J., Zhang, X., 2019. Inflammasome activation restrains the intracellularNeospora caninum proliferation in bovine macrophages. Veterinary parasitology268, 16-20.

9.Wei, Z., Zhao, Y., Zhang, N., Han, Z., Liu, X., Jiang, A., Zhang, Y., Wang, C., Gong, P., Li, J., Zhang, X., Yang, Z., 2019.Eimeria tenellainduces the release of chicken heterophil extracellular

10.Xin, C., Li, J., Gong, P., Wu, B., Zhang, N., Yang, J., Cai, X., Zhang, X., 2019. Viral RNA-based transfection and expression of enhanced green fluorescent protein in the parasitic protozoanEimeria stiedae. Acta biochimica et biophysica Sinica51, 216-218.

11.Zhang, N., Zhang, H., Yu, Y., Gong, P., Li, J., Li, Z., Li, T., Cong, Z., Tian, C., Liu, X., Yu, X., Zhang, X., 2019. High prevalence ofPentatrichomonas hominisinfection in gastrointestinal cancer patients. Parasites & vectors12, 423.

12.Li, L., Wang, X.C., Gong, P.T., Zhang, N., Zhang, X., Li, S., Li, X., Liu, S.X., Zhang, X.X., Li, W., Li, J.H., Zhang, X.C., 2020. ROS-mediated NLRP3 inflammasome activation participates in the response againstNeospora caninuminfection. Parasites & vectors13, 449.

13.Li, X., Zhang, N., Wu, N., Li, J., Yang, J., Yu, Y., Zheng, J., Li, X., Wang, X., Gong, P., Zhang, X., 2020. Identification of GdRFC1 as a novel regulator of telomerase inGiardia duodenalis. Parasitology research119, 1035-1041.

14.Zhang, N., Yu, X., Zhang, H., Cui, L., Li, X., Zhang, X., Gong, P., Li, J., Li, Z., Wang, X., Li, X., Li, T., Liu, X., Yu, Y., Zhang, X., 2020. Prevalence and Genotyping ofCryptosporidium parvumin Gastrointestinal Cancer Patients. Journal of Cancer11, 3334-3339.

15.Gong, P., Li, X., Wu, W., Cao, L., Zhao, P., Li, X., Ren, B., Li, J., Zhang, X., 2020. A Novel MicroRNA From the Translated Region of the Giardiavirus rdrp Gene Governs Virus Copy Number inGiardia duodenalis. Frontiers in microbiology 11, 569412.

16.Wang, X., Li, X., Gong, P., Zhang, N., Li, L., Ouyang, H., Jia, L., Li, J., Zhang, X., 2020. Pyroptosis executioner gasdermin D contributes to host defense and promotes Th 1 immune response duringNeospora caninuminfection. Vet Parasitol 286, 109254.

17.Zhao, P., Zhang, N., Dong, J., Li, J., Wang, X., Li, X., Li, X., Yang, J., Gong, P., Zhang, X., 2020. Effects of Dense Granular Protein 6 (GRA6) Disruption onNeospora caninumVirulence. Frontiers in veterinary science 7, 562730.

18.Dong, J., N. Zhang, P. Zhao, J. Li, L. Cao, X. Wang, X. Li, J. Yang, X. Zhang and P. Gong (2021). "Disruption of Dense Granular Protein 2 (GRA2) Decreases the Virulence ofNeospora caninum." Front Vet Sci 8: 634612.

19.Dong, J., N. Zhang, P. Zhao, J. Li, X. Wang, X. Li, P. Gong and X. Zhang (2021). "GRA12, a novel dense granule protein fromNeospora caninum." Parasitol Int 81: 102268.

20.Li, S., N. Zhang, S. Liu, J. Li, L. Liu, X. Wang, X. Li, P. Gong and X. Zhang (2021). "Protective Immunity AgainstNeospora caninumInfection Induced by 14-3-3 Protein in Mice." Front Vet Sci 8: 638173.

21.Wang, B., N. Zhang, P. Gong, J. Li, X. Wang, X. Li, F. Wang, K. Cai and X. Zhang (2021). "In vitro assays on the susceptibility of four species of nematophagous fungi to anthelmintics and chemical fungicides/antifungal drug." Lett Appl Microbiol 73(2): 124-131.

22.Wang, J., X. Wang, P. Gong, F. Ren, X. Li, N. Zhang, X. Zhang, X. Zhang and J. Li (2021). "The Protective Role of TLR2 Mediates Impaired Autophagic Flux by Activating the mTOR Pathway DuringNeospora caninumInfection in Mice." Front Cell Infect Microbiol 11: 788340.

23.Yue, T. T., N. Zhang, J. H. Li, X. Y. Lu, X. C. Wang, X. Li, H. B. Zhang, S. Q. Cheng, B. B. Wang, P. T. Gong and X. C. Zhang (2021). "Anti-osteosarcoma effect of antiserum against cross antigen TPD52 between osteosarcoma andTrichinella spiralis." Parasit Vectors 14(1): 498.

24.Zhang, X., X. Li, P. Gong, X. Wang, N. Zhang, M. Chen, X. Zhang and J. Li (2021). "Host defense againstNeospora caninuminfection via IL-12p40 production through TLR2/TLR3-AKT-ERK signaling pathway in C57BL/6 mice." Mol Immunol 139: 140-152.

25.Zhang, H., N. Zhang, P. Gong, S. Cheng, X. Wang, X. Li, Z. Hou, C. Liu, T. Bi, B. Wang, Y. Cheng, J. Li and X. Zhang (2022). "Prevalence and molecular characterization ofPentatrichomonas hominisin Siberian tigers (Panthera tigris altaica) in northeast China." Integr Zool.

26.Ding, H., N. Zhang, L. Cao, P. Gong, X. Wang, X. Li, S. Cheng, J. Li and X. Zhang (2022). "First identification of telomeric DNA sequences inTrichomonas vaginalis." Acta Trop 225: 106196.

著作教材

张西臣,李建华主编,《动物寄生虫病学》(第四版),2017年,科学出版社,“十二五”国家级规划教材

获奖情况

1.吉林省科技进步奖二等奖—人兽共患隐孢子虫病诊断与防治技术(1/13),2013J20021;

2.吉林省自然科学奖二等奖—4种原虫病毒的分离鉴定、全基因组破译及转染原虫载体的构建(2/8),2019Z20011;

3.《动物寄生虫病学》国家级精品课,2009年,负责人

4.《动物寄生虫病学》国家精品资源共享课课程,2013年,负责人

5.《动物寄生虫病学》国家级一流本科课程,2020年,负责人

6.“全国农业科研杰出人才”,2012年

7.“吉林省第十一批有突出贡献的中青年专业技术人才”,2010年

8.吉林省第二批拔尖创新人才,2007年

社会兼职

1.中国动物学会寄生虫专业委员会副主任委员;

2.中国畜牧兽医学会兽医寄生虫学分会副理事长;

3.中国动物学会原生动物学分会副理事长;

4.中国兽医协会理事兼动物诊疗分会副会长;

5.吉林省寄生虫学会理事长

联系我们

学院电话:0431-87836150

动物医院电话:0431-87836297 或 87836298

地址:吉林省长春市西安大路5333号