Title：Professor

 Specialties：Veterinary Medicine

 Email：hewq@jlu.edu.cn

Education

Ph.D.  Jilin University               Veterinary Pathology   2009

M.S.   Quartermaster University of PLA     Veterinary Virology  2004

B.S.    Inner Mongolia Agricultural University  Veterinary Medicine  2001

Research Interests:

- Molecular pathology and immunologic pathology of virus infections

- The molecular mechanisms of infection and pathogenicity of neurotropic virus

- Development of the new generation of vaccines against viral diseases

- Animal tumor pathology

Selected Publications：

1. Lan Y(#), Li Z(#), Wang Z, Wang X, Wang G, Zhang J, Hu S, Zhao K, Xu B, Gao F, He W*. An experimental model of neurodegenerative disease based on porcine hemagglutinating encephalomyelitis virus-related lysosomal abnormalities. Molecular Neurobiology. 2020 Sep 2, 57(12): 5299-5306. doi: 10.1007/s12035-020-02105-y.

2. Lv X(#), Li Z(#), Guan J, Hu S, Zhang J, Lan Y, Zhao K, Lu H, Song D, He H, Gao F, He W*. Porcine hemagglutinating encephalomyelitis virus activation of the integrin α5β1-FAK-Cofilin pathway causes cytoskeletal rearrangement to promote its invasion of N2a cells. Journal of Virology. 2019 Feb 19; 93(5). pii: e01736-18.

3. Li Z(#), Zhao K(#), Lv X, Lan Y, Hu S, Shi J, Guan J, Yang Y, Lu H, He H, Gao F, He W*. Ulk1 Governs Nerve Growth Factor/TrkA Signaling by Mediating Rab5 GTPase Activation in Porcine Hemagglutinating Encephalomyelitis Virus-Induced Neurodegenerative Disorders. Journal of Virology. 2018 Jul 31;92(16). pii: e00325-18.

4. Li Z(#), Zhao K(#), Lan Y, Lv X, Hu S, Guan J, Lu H, Zhang J, Shi J, Yang Y, Song D, Gao F, He W*. Porcine hemagglutinating encephalomyelitis virus enters Neuro-2a cells via clathrin-mediated endocytosis in a Rab5-, cholesterol-, and pH-dependent manner. Journal of Virology. 2017 Nov 14; 91(23). pii: e01083-17.

5. Chai Q(#), He W(#), Zhou M, Lu H, Fu ZF. Enhancement of Blood-brain Barrier Permeability and Reduction of Tight Junction Protein Expression Are Modulated by Chemokines/Cytokines induced by Rabies Virus Infection. Journal of Virology. 2014 May; 88(9): 4698-710.

6. Zhao K(#), He W(#), Xie S, Song D, Lu H, Pan W, Zhou P, Liu W, Lu R, Zhou J*, Gao F*. Highly pathogenic fowlpox virus in cutaneously infected chickens, china. Emerging infectious diseases, 2014 Jul; 20(7): 1208-2010. doi: 10.3201/eid2007.131118.