WANG Jianfeng

Title： Associate Professor

Specialties：Veterinary Medicine

Email：wjf927@jlu.edu.cn

                               Wang Jianfeng obtained his B.Sc. in Veterinary Medicine from Jilin University in 2010. He then did his Ph.D. with Prof. DENG Xuming in “Veterinary Pharmacology”. He is mainly engaged in the research on the anti-bacteria infection by Traditional Chinese Medicine, as well as the mechanism of such effect. In recent years, he has found that TCM exists anti-infection against bacteria by targeting virulence factors (bacterial hemolysin, sortase and coagulase) and resistance enzymes (NDM and MCR). These findings partly revealed the mechanism of TCM against bacterial infection.

Research Interests：

· The anti-bacteria infection by Traditional Chinese Medicine.

Selected Publications： 

1. Liu S(#), Zhang J(#), Zhou Y, Hu N, Li J, Wang Y, Niu X, Deng X*, Wang J*. Pterostilbene restores carbapenem susceptibility in New Delhi metallo-β-lactamase-producing isolates by inhibiting the activity of New Delhi metallo-β-lactamases. Br J Pharmacol. 2019 Aug 2. doi: 10.1111/bph.14818.

2. Li H(#), Chen Y(#), Zhang B(#), Niu X, Song M, Luo Z, Lu G, Liu B, Zhao X, Wang J*, Deng X*. Inhibition of sortase A by chalcone prevents Listeria monocytogenes infection. Biochem Pharmacol. 2016 Apr 15;106:19-29. pii: S0006-2952(16)00042-3.

3. Guo Y(#), Lv X(#), Wang Y, Zhou Y, Lu N, Deng X, Wang J*. Honokiol restores polymyxins susceptibility to MCR-1-positive pathogens both in vitro and in vivo. Appl Environ Microbiol. 2019 Dec 20. pii: AEM.02346-19.

4. Shen X(#), Niu X(#), Li G, Deng X*, Wang J*. Amentoflavone Ameliorates Streptococcus suis-Induced Infection In Vitro and In Vivo. Appl Environ Microbiol. 2018 Dec 15;84(24) pii: AEM.01804-18.

5. Zhou Y(#), Wang J(#), Guo Y, Liu X, Liu S, Niu X, Wang Y*, Deng X*. Discovery of a potential MCR-1 inhibitor that reverses polymyxin activity against clinical mcr-1-positive Enterobacteriaceae. J Infect. 2019 May;78(5):364-372. pii: S0163-4453(19)30073-8.