LIU Guowen           

Title：Professor/Deputy Dean            

Specialties：Animal Nutrition Metabolic Disease

Email：liuguowen2008@163.com; gwliu@jlu.edu.cn

Guowen Liu is a Professor of Jilin University, the PI of Animal Nutrition Metabolic Disease Research Center in Jilin University. Dr. Liu earned his Bachelor's degree from Inner Mongolia University for Nationalities in 1997, and received his Ph.D. from Jilin University in 2004. He is member of Chinese Society of Veterinary Internal Medicine and member of Chinese Society of Animal Toxicology. His recent interests include pathological mechanism of ketosis, fatty liver, SARA and hypocalcemia of dairy cows, and molecular mechanism of nutrient metabolism homeostasis. In recent years, presided more than 10 projects form the National Natural Science Foundation, Ministry of Science and Technology. More than 80 papers have been published in important international journals, such as J Dairy Sci, J Cell Physiol, Br J Pharmacol, Front Cell Dev Biol, etc. 

Research Interests：                        

·The molecular mechanism of Animal Nutritional and Metabolic Disorders (Cow: ketosis, fatty liver, SARA, hypocalcemia)

·The mechanism role of Autophagy, Oxidative stress, Inflammation, Mitochondrial dysfunction, Endoplasmic reticulum stress, and Intestinal flora in the fatty liver, diabetes, and obesity. 

Selected Publications：

1. Li, X…Du, X.*, & Liu, G.* (2020). Cyanidin-3-O-glucoside improves non-alcoholic fatty liver disease by promoting PINK1-mediated mitophagy in mice. Br J Pharmacol, IF: 7.73, JCR Q1, Top.

2. Shen, T… Liu, G.* (2019). Hepatic nuclear factor kappa B signaling pathway and NLR family pyrin domain containing 3 inflammasome is over-activated in ketotic dairy cows. J Dairy Sci, IF: 3.33, JCR Q1, TOP.

3. Du, X…Li, X.*, & Liu, G.* (2018). High concentrations of fatty acids and β-hydroxybutyrate impair the growth hormone-mediated hepatic JAK2-STAT5 pathway in clinically ketotic cows. J Dairy Sci, IF: 3.33, JCR Q1, TOP. Cover Paper; Highly Cited Paper.

4. Du, X…Liu, G.*, & Li, X.* (2017). Acetoacetate induces hepatocytes apoptosis by the ROS-mediated MAPKs pathway in ketotic cows. J Cell Physiol, IF: 5.546, JCR Q1, Highly Cited Paper.

5. Song, Y... Li, X.*, & Liu, G. *(2016). β-Hydroxybutyrate induces bovine hepatocyte apoptosis via an ROS-p38 signaling pathway. J Dairy Sci, IF: 3.33, JCR Q1, TOP. Highly Cited Paper. 

Awards：

1. The first prize of Natural Academic Achievements of Jilin Province

2. American Dairy Science Association Highly Cited Paper Award

3. New Century Excellent Talents in University