DENG Xuming
Title：Professor
Specialties：Veterinary Medicine
Email：dengxm@jlu.edu.cn
Deng Xuming obtained his B.Sc. in Veterinary Medicine from Hunan Agricultural University in 1984. He then did his M.S. and Ph.D. in “Veterinary Medicine” from University of Changchun Veterinary Medicine. In recent years, he received Key Program, Project of international cooperation and exchanges and General Program from the National Natural Science Foundation of China. He has made breakthroughs in the study of the mechanism of anti-bacteria infection by Traditional Chinese Medicine, as well as the clinical application of TCM for bacteria infection, providing new strategy to fight bacteria infection with TCM.
Research Interests：
· Discovery of new targets and leading compounds against bacterial infection.
· The mechanism of TCM against inflammatory response.
Selected Publications：
1. Liu S(#), Zhang J(#), Zhou Y, Hu N, Li J, Wang Y, Niu X, Deng X*, Wang J*. Pterostilbene restores carbapenem susceptibility in New Delhi metallo-β-lactamase-producing isolates by inhibiting the activity of New Delhi metallo-β-lactamases. Br J Pharmacol. 2019 Aug 2. doi: 10.1111/bph.14818.
2. Zhou Y(#), Liu S(#), Wang T, Li H, Tang S, Wang J, Wang Y*, Deng X*. Pterostilbene, a Potential MCR-1 Inhibitor That Enhances the Efficacy of Polymyxin B. Antimicrob Agents Chemother. 2018 Apr;62(4) pii: AAC.02146-17.
3. Dong J(#), Zhang Y(#), Chen Y(#), Niu X, Zhang Y, Li R, Yang C, Wang Q, Li X*, Deng X*. Baicalin inhibits the lethality of ricin in mice by inducing protein oligomerization. J Biol Chem. 2015 May 15;290(20):12899-907. pii: M114.632828.
4. Li H(#), Chen Y(#), Zhang B(#), Niu X, Song M, Luo Z, Lu G, Liu B, Zhao X, Wang J*, Deng X*. Inhibition of sortase A by chalcone prevents Listeria monocytogenes infection. Biochem Pharmacol. 2016 Apr 15;106:19-29. pii: S0006-2952(16)00042-3.
5. Dong J(#), Zhang Y(#), Chen Y(#), Niu X, Zhang Y, Yang C, Wang Q, Li X*, Deng X*. Baicalin inhibits the lethality of Shiga-like toxin 2 in mice. Antimicrob Agents Chemother. 2015 Nov;59(11):7054-60. pii: AAC.01416-15.
Awards：
1. Science Technology Improvement Award of Science Research Famous Achievement Award in Higher Institution (Second prize). The target and mechanism of natural compounds against drug resistant Staphylococcus aureus. (1/10)
