LAI Liangxue            

  Title:  Professor            

  Specialties：Basic Veterinary Medicine

  Email：lai_liangxue@gibh.ac.cn 

LAI Liangxue graduated from Sichuan Animal Husbandry and Veterinary College with a bachelor's degree in agronomy in 1984, a master's degree in animal anatomy from the Veterinary University of the Chinese people's Liberation Army in 1987, and a doctor of science from the Department of Biological Engineering of Northeast Agricultural University in 1995. He has been engaged in the research of pig embryo bioengineering and developmental biology since 1992. He worked in postdoctoral research at the Animal Research Center of the University of Missouri in 1998 and was promoted to Assistant Professor of Research at the Animal Research Center of the University of Missouri in 2002. He served as an assistant professor of research at the National Pig Resources Conservation and Research Center of the University of Missouri from 2004 to 2006. In July 2007, he was appointed as a chief scientist of Jilin key Laboratory of Animal embryo Engineering, Jilin University.

Research Interests：                        

· Optimization of Gene Editing Technology

·Construction and Application of Animal Model

Selected Publications:

1. Tingting Sui ^#; Yuning Song^#; Zhiquan Liu; Mao Chen; Jichao Deng;Yuanyuan Xu; Liangxue Lai *; Zhanjun Li*, CRISPR-induced exon skipping is dependent on premature termination codon mutations. Genome Biology 2018, 19:164

2. Zhiquan Liu ; Mao Chen ; Siyu Chen ; Jichao Deng; Yuning Song; Liangxue Lai ; Zhanjun Li; Highly efficient RNA-guided base editing in rabbit, Nature Communications, 2018.07.13, 9(1)

3. Yuning Song^#; Yuxin Zhang ^#; Mao Chen; Jichao Deng; Tingting Sui; Liangxue Lai*; Zhanjun Li*, Functional validation of the albinism-associated tyrosinase T373K SNP by CRISPR/Cas9-mediated homology-directed repair (HDR) in rabbits, EBioMedicine, 2018, 36.517-525

4. Yuning Song^#; Lin Yuan^#; Yong Wang; Mao Chen; Jichao Deng; Qingyan Lv; Tingting Sui; Zhanjun Li *; Liangxue Lai *, Efficient dual sgRNAdirected large gene deletion in rabbit with CRISPR/Cas9 system., Cell Mol Life Sci, 2016.1.27, 73(15): 2959-2968

Awards：

1. Winner of the highest award for medical technology in the American New Age of Science and Technology magazine in 2002.

2. The two research results ranked among the top 30 of the world's top 100 science and technology news by Discovery magazine in 2002 and 2006 respectively.

3. Winner of China overseas Outstanding Youth Fund.