XU Xiaohong

Title: Postdoctoral/Lecture

Specialties: Virology, Vaccine, Avian Immunology

Email: xuxiaohong@jlu.edu.cn

Xiaohong Xu obtained her B.Sc. in Veterinary Medicine from Chinese Agricultural University in 2012. In 2016, she went to Jilin University did her Ph.D. with Prof. Zhuang Ding in “Zoonosis”. In 2019, as a postdoctoral fellow, she joined Prof. Zhuang Ding’s and Prof. Ningyi Jin’s group , and did research on the mechanism of bi-directional regulation of exosome in Newcastle Disease Virus infection. In 2020, she received the support of National Science Foundation for Young Scientists of China.

Research Interests：                        

·Development of novel vaccines against animal infectious pathogens

·Mechanisms of innate avian immunology

·Exosome mediated viral infection and antiviral response

·Epidemiology of Newcastle Disease Virus

Selected Publications：

1. Xiaohong Xu, Jindou Li, Jiaxin Ding, Jing Qian, Lingsong Qin, Cong Xue, Jianzhong Wang, Weiqi Wang, Wei Ding, Zhuang Ding, Renfu Yin, Chimeric Newcastle disease virus-like particles containing DC-binding peptide-fused haemagglutinin protect chickens from virulent Newcastle disease virus and H9N2 avian influenza virus challenge. Virol Sin.Xiaohong Xu, Zhuang Ding, Qianliang Yuan, Jiaxin Ding, Jindou Li, Weiqi Wang, Yanlong Cong, Wei Ouyang, Yongshan Wang, Jing Qian, Renfu Yin, A genotype VII Newcastle disease virus-like particles confer full protection with reduced virus load and decreased virus shedding [J]. Vaccine. 2019, 37(3):444-451.

2. Xiaohong Xu, Cong Xue, Xinxin Liu, Junjiao Li, Yidong Fei, Zhe Liu, Jiaqi Mu, Yuhai Bi, Jing Qian, Renfu Yin, Zhuang Ding, A novel recombinant attenuated Newcastle disease virus expressing H9 subtype hemagglutinin protected chickens from challenge by genotype VII virulent Newcastle disease virus and H9N2 avian influenza virus [J]. Vet Microbiol. 2019, 228:173-180.

3. Xiaohong Xu, Zhuang Ding, Jindou Li, Jiaming Liang, Zhaoyang Bu, Jiaxin Ding, Yanling Yang, Xulong Lang, Xinglong Wang, Renfu Yin, Jing Qian, Newcastle disease virus-like particles containing the Brucella BCSP31 protein induce dendritic cell activation and protect mice against virulent Brucella challenge [J]. Vet Microbiol. 2019, 229:39-47.  

5. Xiaohong Xu, Jiaxin Ding, Jindou Li, Cong Xue, Jianzhong Wang, Yanlong Cong, Renfu Yin, Mingxi Yang, Jing Qian, Zhuang Ding, Evaluation of the safety and protection efficacy of an attenuated genotype VII Newcastle disease virus strain as a candidate vaccine, Microb Pathog.